PerspectiveGenetic Diseases

Deep Sequencing of Patient Genomes for Disease Diagnosis: When Will It Become Routine?

Science Translational Medicine  15 Jun 2011:
Vol. 3, Issue 87, pp. 87ps23
DOI: 10.1126/scitranslmed.3002695

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Abstract

Next-generation sequencing technologies have greatly lowered the cost of whole-genome sequencing (WGS) and related approaches. Thus, comprehensive sequencing for diagnostic purposes may clear this financial hurdle in the near future. The report by Bainbridge and colleagues in this issue of Science Translational Medicine illustrates the diagnostic power of WGS. In this Perspective, we discuss whether and how genome sequencing might become routine for clinical diagnosis.

Footnotes

  • Citation: S. F. Kingsmore, C. J. Saunders, Deep Sequencing of Patient Genomes for Disease Diagnosis: When Will It Become Routine? Sci. Transl. Med. 3, 87ps23 (2011).

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