Contents
Vol 3, Issue 84
Contents
Commentary
- Quality Versus Quantity: Assessing Individual Research Performance
Bibliometrics could potentially improve objective evaluation of individual researchers, if qualitative measurements are included.
Perspective
- Therapeutic Antibodies for Brain Disorders
A bispecific human monoclonal antibody targeting the transferrin receptor and an enzyme implicated in Alzheimer's disease enters the brain through receptor-mediated transcytosis.
Research Articles
- A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
A human antibody inhibits BACE1 activity and Aβ peptide production in cultured neurons and in the central nervous system of mouse and monkey.
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Brain uptake of a therapeutic bispecific antibody by receptor-mediated transcytosis is enhanced by reducing the antibody’s affinity for the transferrin receptor.
- Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques
Indocyanine green, a clinically approved near-infrared fluorescence imaging agent, rapidly targets atheromas for in vivo detection of lipid-rich, inflammatory plaques.
Editors' Choice
- The Transcriptome Speaks
RNA sequencing reveals chimeric gene transcripts enriched in human prostate cancer.
- Understanding PPAR-γ Action—Just Use Your Brain!
PPAR-γ action in the brain explains thiazolidinedione-related weight gain and is required for thiazolidinedione's effects to improve hepatic insulin sensitivity.
- Breathing Easier
Multipotent stem cells in the human lung may have potential for repairing injured or diseased lung tissue.
- Construction–Deconstruction–Reconstruction
Tissue-engineered allogeneic blood vessels have potential in cardiac bypass surgery.
Podcast
- Science Translational Medicine Podcast: 25 May 2011
A conversation with Steven M. Paul about a designer therapeutic antibody with potential for treating Alzheimer’s disease.