Contents

Contents

• Commentary

  • Quality Versus Quantity: Assessing Individual Research Performance

    By José-Alain Sahel

    Science Translational Medicine25 May 2011 : 84cm13 Full AccessRestricted Access

    Bibliometrics could potentially improve objective evaluation of individual researchers, if qualitative measurements are included.

    • Abstract
    • Full Text
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• Perspective

  • Therapeutic Antibodies for Brain Disorders

    By Steven M. Paul

    Science Translational Medicine25 May 2011 : 84ps20 Full AccessRestricted Access

    A bispecific human monoclonal antibody targeting the transferrin receptor and an enzyme implicated in Alzheimer's disease enters the brain through receptor-mediated transcytosis.

    • Abstract
    • Full Text
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• Research Articles

  • A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

    By Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu, Deborah L. Mortensen, William J. Meilandt, Yichin Liu, Christopher E. Heise, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kun Peng, Ping Wu, Lionel Rouge, Yingnan Zhang, Robert A. Lazarus, Kimberly Scearce-Levie, Weiru Wang, Yan Wu, Marc Tessier-Lavigne, Ryan J. Watts

    Science Translational Medicine25 May 2011 : 84ra43 Full AccessRestricted Access

    A human antibody inhibits BACE1 activity and Aβ peptide production in cultured neurons and in the central nervous system of mouse and monkey.

    • Editor's Summary
    • Abstract
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  • Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

    By Y. Joy Yu, Yin Zhang, Margaret Kenrick, Kwame Hoyte, Wilman Luk, Yanmei Lu, Jasvinder Atwal, J. Michael Elliott, Saileta Prabhu, Ryan J. Watts, Mark S. Dennis

    Science Translational Medicine25 May 2011 : 84ra44 Full AccessRestricted Access

    Brain uptake of a therapeutic bispecific antibody by receptor-mediated transcytosis is enhanced by reducing the antibody’s affinity for the transferrin receptor.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques

    By Claudio Vinegoni, Ion Botnaru, Elena Aikawa, Marcella A. Calfon, Yoshiko Iwamoto, Eduardo J. Folco, Vasilis Ntziachristos, Ralph Weissleder, Peter Libby, Farouc A. Jaffer

    Science Translational Medicine25 May 2011 : 84ra45 Full AccessRestricted Access

    Indocyanine green, a clinically approved near-infrared fluorescence imaging agent, rapidly targets atheromas for in vivo detection of lipid-rich, inflammatory plaques.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • The Transcriptome Speaks

    By Samir Damani

    Science Translational Medicine25 May 2011 : 84ec76 Full AccessRestricted Access

    RNA sequencing reveals chimeric gene transcripts enriched in human prostate cancer.

    • Full Text

  • Understanding PPAR-γ Action—Just Use Your Brain!

    By Carmella Evans-Molina

    Science Translational Medicine25 May 2011 : 84ec77 Full AccessRestricted Access

    PPAR-γ action in the brain explains thiazolidinedione-related weight gain and is required for thiazolidinedione's effects to improve hepatic insulin sensitivity.

    • Full Text

  • Breathing Easier

    By Richard J. Lin

    Science Translational Medicine25 May 2011 : 84ec78 Full AccessRestricted Access

    Multipotent stem cells in the human lung may have potential for repairing injured or diseased lung tissue.

    • Full Text

  • Construction–Deconstruction–Reconstruction

    By Christopher L. Skelly

    Science Translational Medicine25 May 2011 : 84ec79 Full AccessRestricted Access

    Tissue-engineered allogeneic blood vessels have potential in cardiac bypass surgery.

    • Full Text

• Podcast

  • Science Translational Medicine Podcast: 25 May 2011

    By Steven M. Paul, Orla Smith

    Science Translational Medicine25 May 2011 : 84pc7 Full AccessRestricted Access

    A conversation with Steven M. Paul about a designer therapeutic antibody with potential for treating Alzheimer’s disease.

    • Abstract