PerspectiveTransplantation and Autoimmune Disease

Regulatory T Cells: Customizing for the Clinic

Science Translational Medicine  18 May 2011:
Vol. 3, Issue 83, pp. 83ps19
DOI: 10.1126/scitranslmed.3001819

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Abstract

Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific regulatory T cells (Treg cells), lymphocytes that suppress certain immune responses. Together, three papers in this issue of Science Translational Medicine describe protocols for the ex vivo expansion of human Treg cells and assess the immune-suppressive function of ex vivo–manipulated Treg cells after transfer into humanized mouse disease models. Along with recent phase I clinical trial results, these new data provide a platform for clinical use of Treg cells as personalized therapeutic agents for the treatment of autoimmune diseases, graft-versus-host disease, and transplant rejection.

Footnotes

  • Citation: X. Wang, L. Lu, S. Jiang, Regulatory T Cells: Customizing for the Clinic. Sci. Transl. Med. 3, 83ps19 (2011).

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