PerspectiveInflammasome

The Inflammasome in Atherosclerosis and Type 2 Diabetes

Science Translational Medicine  04 May 2011:
Vol. 3, Issue 81, pp. 81ps17
DOI: 10.1126/scitranslmed.3001902

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors, such as cholesterol crystals in atherosclerosis, or hyperglycemia, ceramides, and islet amyloid polypeptide in type 2 diabetes. Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis.

Footnotes

  • Citation: S. L. Masters, E. Latz, L. A. J. O’Neill, The Inflammasome in Atherosclerosis and Type 2 Diabetes, Sci. Transl. Med. 3, 81ps17 (2011).

View Full Text