State of the Art ReviewNeurodegenerative Disease

Alzheimer’s Disease: The Challenge of the Second Century

Science Translational Medicine  06 Apr 2011:
Vol. 3, Issue 77, pp. 77sr1
DOI: 10.1126/scitranslmed.3002369

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  1. Article
    1. Abstract
    2. Overview
    3. Clinical Features of AD
    4. The Pathological Process in AD
    5. AD Genetics and Link to Pathophysiology
    6. The Connection Among APP, Aβ, and Presenilins
    7. Apolipoprotein E, the Environment, and AD
    8. Connecting Aβ and Tau
    9. Prevention of Aβ and Tau Aggregation
    10. The Conundrum Among Biomarkers, Pathology, and Treatment
    11. Summary
    12. Footnotes
    13. References
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