HIV Transmission: Time for Translational Studies to Bridge the Gap

Science Translational Medicine  06 Apr 2011:
Vol. 3, Issue 77, pp. 77ps11
DOI: 10.1126/scitranslmed.3002329

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More than 7000 new HIV infections are documented each day worldwide. In this Perspective, we dissect new results from a large clinical trial showing that genital and plasma HIV-1 RNA loads predict the risk of heterosexual transmission and that genital tract viral RNA load does so independently of plasma viral load. Furthermore, beyond its defined study end points, this well-conducted trial identified new research directions that should be pursued in smaller intensive basic and translational studies.

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