PerspectiveRegenerative Medicine

Human Pluripotent Stem Cells: Decoding the Naïve State

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Science Translational Medicine  30 Mar 2011:
Vol. 3, Issue 76, pp. 76ps10
DOI: 10.1126/scitranslmed.3000996

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Human pluripotent stem cells play a central role in regenerative medicine and tissue engineering. These versatile cells can exist in a range of manipulable states with distinct functionalities, from the late epiblast stage represented by the conventional human embryonic stem cells (hESCs) to the mouse ESC-like naïve state. These functional states must be fully characterized if we are to harness the power of pluripotent stem cells to transform clinical medicine and therapeutics discovery.

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