Research ArticleAging

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

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Science Translational Medicine  16 Feb 2011:
Vol. 3, Issue 70, pp. 70ra13
DOI: 10.1126/scitranslmed.3001845

Article Information

vol. 3 no. 70 70ra13

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 25, 2010
  • Accepted for publication January 26, 2011

Author Information

  1. Jaime Guevara-Aguirre1,*,
  2. Priya Balasubramanian2,3,*,
  3. Marco Guevara-Aguirre1,
  4. Min Wei3,
  5. Federica Madia3,
  6. Chia-Wei Cheng3,
  7. David Hwang4,
  8. Alejandro Martin-Montalvo5,6,
  9. Jannette Saavedra1,
  10. Sue Ingles7,
  11. Rafael de Cabo5,
  12. Pinchas Cohen4 and
  13. Valter D. Longo2,3,8,
  1. 1Institute of Endocrinology, Metabolism and Reproduction, Quito, Ecuador.
  2. 2Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
  3. 3Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA.
  4. 4Division of Pediatric Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  5. 5Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, MD 21224, USA.
  6. 6Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide–Consejo Superior de Investigaciones Cientificas and Centre for Biomedical Research on Rare Diseases, ISCIII, E-41013 Sevilla, Spain.
  7. 7Division of Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
  8. 8Norris Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
  1. To whom correspondence should be addressed. E-mail: jguevara{at}iemyr-ecuador.org (J.G.-A.); vlongo{at}usc.edu (V.D.L.).

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