Leukotriene Inflammatory Mediators Meet Their Match

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Science Translational Medicine  19 Jan 2011:
Vol. 3, Issue 66, pp. 66ps3
DOI: 10.1126/scitranslmed.3002040

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Leukotrienes are arachidonic acid–derived lipid mediators of inflammation. The initial catalytic step in the formation of leukotrienes is catalyzed by 5-lipoxygenase (5-LOX) in conjunction with its activating partner protein FLAP. The long-awaited crystal structure of 5-LOX—reported in a recent issue of Science—should lead to novel, purpose-designed inhibitors for the treatment of asthma and for probing leukotriene involvement in cardiovascular disease and cancer.


  • Citation: C. D. Funk, Leukotriene Inflammatory Mediators Meet Their Match. Sci. Transl. Med. 3, 66ps3 (2011).

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