PerspectiveNeuropharmacology

Epigenetics of Nicotine: Another Nail in the Coughing

Science Translational Medicine  02 Nov 2011:
Vol. 3, Issue 107, pp. 107ps43
DOI: 10.1126/scitranslmed.3003278

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Abstract

In a mouse model, chronic nicotine exposure before cocaine use exacerbated the epigenetic, gene-expression, electrophysiological, and behavioral effects that occur during the transition from acute to chronic responses to cocaine that have been linked with the addictive process. Nicotine enhancement of the effects can be mimicked with an inhibitor of chromatin-modifying enzymes (class I and II histone deacetylases). These findings may spur the discovery of therapeutics for the treatment of addiction.

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