PerspectiveOncogene Addiction

Striking a Balance Between Feasible and Realistic Biological Models

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Science Translational Medicine  05 Oct 2011:
Vol. 3, Issue 103, pp. 103ps39
DOI: 10.1126/scitranslmed.3003079

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Abstract

The fusion of empirical science with large-scale computing platforms has allowed rapid advances in our ability to model physiological and pathophysiological processes in silico. In this week’s issue of Science Translational Medicine, Tran et al. present a simple framework for the quantitative modeling of oncogene addiction that provides mechanistic insights into tumor biology.

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