21 September 2011
Vol 3, Issue 101

About The Cover

Cover image expansion

ONLINE COVER Lightning Strikes. A confocal fluorescent image of nerve fibers containing the pain-related peptide CGRP (white) that extend from the vulvar lamina propria to the epithelial cell layer in mouse. Found at high density in the vulva of animals repeatedly infected with the yeast Candida albicans, these sensory nerve fibers persist even after resolution of the infection, as Farmer et al. describe. Such hyperinnervation may be responsible for the pain signals that cause vulvodynia, a common disorder characterized by intense, unexplained pain of the vulva. [CREDIT: A. TUTTLE/MCGILL UNIVERSITY]