Contents

20 October 2010
Vol 2, Issue 54

About The Cover

Cover image expansion

ONLINE COVER Illuminating Depression. Depicted is a cross section through the brain showing a region called the nucleus accumbens (red). There is decreased expression of the p11 protein in the nucleus accumbens of postmortem brain tissue from depressed individuals, and this decrease is associated with depressive behaviors in mice. As outlined in this week's Research Article by Alexander et al. and discussed in the Perspective by Chen et al., boosting p11 expression in the nucleus accumbens alleviates depression in mice, suggesting that this protein and brain region may be new therapeutic targets for developing antidepressants.
[CREDIT: Y. HAMMOND/C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]