Contents
Vol 2, Issue 54
Contents
Perspectives
- Metabolic Syndromes and Malignant Transformation: Where the Twain Shall Meet
A subset of patients with a rare metabolic disorder, D-2-hydroxyglutaric aciduria, houses a germline mutation that is similar to certain somatic mutations seen in brain and blood cancers.
- p11 and Gene Therapy for Severe Psychiatric Disorders: A Practical Goal?
Levels of the p11 protein in the nucleus accumbens brain region are lower in individuals with depression, and p11 appears to modulate depression-related behaviors in mice.
Research Articles
- Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens
Reduction of the 5-HT1B receptor–binding protein p11 in the mouse nucleus accumbens induces depression-like behaviors, and gene therapy to restore p11 expression in this region reverses depression-like behaviors.
- An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer
Drug-induced transcription and epigenetic changes can predict whether liver cancer can be successfully treated with an epigenome-targeting drug.
Editors' Choice
- When Too Much Oxygen Is Not Too Much
Breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury in mouse and human lung.
- Blunting Pain at a Distance
Anandamide—a natural transmitter—stimulates cannabinoid receptors located outside the brain to cause analgesia, pointing to a new target for pain relief that may have fewer risks and side effects.
- Epidermal Growth Factor Receptor: Not Just Epidermal
Inhibition of epidermal growth factor receptor enhances granulocyte colony–stimulating factor–induced mobilization of hematopoietic stem and progenitor cells.
- Stop Poking Me! New Implantable Microbeads for Continuous Glucose Monitoring
New implantable microbeads offer a minimally invasive alternative to finger pricks for glucose monitoring.
