Research ArticleParkinson’s Disease

PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

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Science Translational Medicine  06 Oct 2010:
Vol. 2, Issue 52, pp. 52ra73
DOI: 10.1126/scitranslmed.3001059

Article Information

vol. 2 no. 52 52ra73

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History: 
  • Received for publication March 11, 2010
  • Accepted for publication September 15, 2010

Author Information

  1. Bin Zheng1,
  2. Zhixiang Liao1,
  3. Joseph J. Locascio2,
  4. Kristen A. Lesniak3,
  5. Sarah S. Roderick1,
  6. Marla L. Watt3,
  7. Aron C. Eklund1,4,
  8. Yanli Zhang-James5,
  9. Peter D. Kim6,
  10. Michael A. Hauser7,
  11. Edna Grünblatt8,
  12. Linda B. Moran9,
  13. Silvia A. Mandel10,
  14. Peter Riederer8,
  15. Renee M. Miller11,
  16. Howard J. Federoff12,
  17. Ullrich Wüllner13,
  18. Spyridon Papapetropoulos14,15,
  19. Moussa B. Youdim10,16,
  20. Ippolita Cantuti-Castelvetri2,
  21. Anne B. Young2,
  22. Jeffery M. Vance17,
  23. Richard L. Davis18,
  24. John C. Hedreen19,
  25. Charles H. Adler20,
  26. Thomas G. Beach21,
  27. Manuel B. Graeber22,
  28. Frank A. Middleton18,
  29. Jean-Christophe Rochet3,
  30. Clemens R. Scherzer1,23,* and
  31. the Global PD Gene Expression (GPEX) Consortium
  1. 1Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA.
  2. 2Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  3. 3Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
  4. 4Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
  5. 5Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  6. 6Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  7. 7Department of Medicine, Duke University, Durham, NC 27708, USA.
  8. 8Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Research Laboratory, University of Würzburg, 97070 Würzburg, Germany.
  9. 9North Wembley, Middlesex HAO 3QJ, UK.
  10. 10Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine, Haifa 31096, Israel.
  11. 11Center for Neural Development and Disease, University of Rochester, Rochester, NY 14620, USA.
  12. 12Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA.
  13. 13Department of Neurology, Friedrich-Wilhelms-University Bonn, UKB, 53105 Bonn, Germany.
  14. 14Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
  15. 15Allergan, Irvine, CA 92623-9534, USA.
  16. 16Department of Biology, Yonsei World Central University, Seoul 120-749, South Korea.
  17. 17Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
  18. 18Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  19. 19Harvard Brain Tissue Resource Center, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA.
  20. 20Mayo Division of Movement Disorders, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
  21. 21W. H. Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, AZ 85259, USA.
  22. 22The Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales 2050, Australia.
  23. 23Harvard NeuroDiscovery Center Biomarker Program, Cambridge, MA 02139, USA.
  1. *To whom correspondence should be addressed. E-mail: cscherzer{at}rics.bwh.harvard.edu

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