Research ArticleEpigenetics

Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

Science Translational Medicine  15 Sep 2010:
Vol. 2, Issue 49, pp. 49ra67
DOI: 10.1126/scitranslmed.3001262

You are currently viewing the abstract.

View Full Text

Log in


Abstract

The epigenome consists of non–sequence-based modifications, such as DNA methylation, that are heritable during cell division and that may affect normal phenotypes and predisposition to disease. Here, we have performed an unbiased genome-scale analysis of ~4 million CpG sites in 74 individuals with comprehensive array-based relative methylation (CHARM) analysis. We found 227 regions that showed extreme interindividual variability [variably methylated regions (VMRs)] across the genome, which are enriched for developmental genes based on Gene Ontology analysis. Furthermore, half of these VMRs were stable within individuals over an average of 11 years, and these VMRs defined a personalized epigenomic signature. Four of these VMRs showed covariation with body mass index consistently at two study visits and were located in or near genes previously implicated in regulating body weight or diabetes. This work suggests an epigenetic strategy for identifying patients at risk of common disease.

Footnotes

  • * These authors contributed equally to this work.

  • Present address: INSERM, Paris 75014, France.

  • Citation: A. P. Feinberg, R. A. Irizarry, D. Fradin, M. J. Aryee, P.Murakami, T. Aspelund, G. Eiriksdottir, T. B. Harris, L. Launer, V. Gudnason, M. D. Fallin, Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci. Transl. Med. 2, 49ra67 (2010).

View Full Text