PerspectiveTumor Immunotherapy

Coupled for Cross-Presentation in Tumor Immunotherapy

Science Translational Medicine  11 Aug 2010:
Vol. 2, Issue 44, pp. 44ps40
DOI: 10.1126/scitranslmed.3001245

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Abstract

Antigen cross-presentation is a critical step in the elicitation of cell-mediated immune responses. Much research has been aimed at manipulating antigen cross-presentation to improve tumor immunotherapy and vaccination. In this issue of Science Translational Medicine, Saccheri et al. describe a mechanism for spurring successful antitumor responses by enhancing the transfer, to antigen-presenting cells, of tumor-specific antigens that leave the cancer cells via gap junctions induced by Salmonella infection of the melanoma tumor. Salmonella turns from foe to friend by promoting cross-presentation for strong antitumor immunity and tumor eradication.

Footnotes

  • Citation: B. Pang, J. Neefjes, Coupled for cross-presentation in tumor immunotherapy. Sci. Transl. Med. 2, 44ps40 (2010).

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