Perspectivehepatitis C

Rong’s Numbers: Accelerating Progress in HCV Therapeutic Research

Science Translational Medicine  26 May 2010:
Vol. 2, Issue 33, pp. 33ps25
DOI: 10.1126/scitranslmed.3001183

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Abstract

Rong and colleagues have applied a mathematical model of hepatitis C virus (HCV) replication to experimental data from initial clinical investigations of HCV protease inhibitors. In this Perspective, we discuss how mathematical modeling and other modern translational research tools and approaches can be used to expedite drug development with well-designed combination clinical trials that test drugs from multiple collaborators.

Footnotes

  • Citation: D. L. Wyles, R. T. Schooley, Rong’s numbers: Accelerating progress in HCV therapeutic research. Sci. Transl. Med. 2, 33ps25 (2010).

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