PerspectiveHIV/AIDS

Insights into Therapy: Tryptophan Oxidation and HIV Infection

Science Translational Medicine  19 May 2010:
Vol. 2, Issue 32, pp. 32ps23
DOI: 10.1126/scitranslmed.3001082

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Abstract

New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway—via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2—and chronic inflammation in progressive HIV disease. It can now be appreciated that a pathogenic TOx activation cycle exists in HIV. TOx regulation is a therapeutic target for other diseases, such as cancer and autoimmune disorders. Here TOx control is examined with an eye to eventual therapeutic intervention in HIV disease.

Footnotes

  • Citation: M. F. Murray, Insights into therapy: Tryptophan oxidation and HIV infection. Sci. Transl. Med. 2, 32ps23 (2010).

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