Research ArticleCancer

Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development

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Science Translational Medicine  07 Apr 2010:
Vol. 2, Issue 26, pp. 26ra25
DOI: 10.1126/scitranslmed.3000251

Article Information

vol. 2 no. 26 26ra25

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History: 
  • Received for publication July 6, 2009
  • Accepted for publication March 19, 2010

Author Information

  1. Adam M. Gustafson1,2,*,
  2. Raffaella Soldi3,*,
  3. Christina Anderlind1,
  4. Mary Beth Scholand4,
  5. Jun Qian5,
  6. Xiaohui Zhang1,
  7. Kendal Cooper3,
  8. Darren Walker3,
  9. Annette McWilliams6,
  10. Gang Liu1,
  11. Eva Szabo7,
  12. Jerome Brody1,
  13. Pierre P. Massion5,
  14. Marc E. Lenburg1,2,8,
  15. Stephen Lam6,
  16. Andrea H. Bild3,* and
  17. Avrum Spira1,2,8,*
  1. 1Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA.
  2. 2Bioinformatics Program, Boston University, Boston, MA 02118, USA.
  3. 3Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
  4. 4School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.
  5. 5Division of Allergy Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt-Ingram Comprehensive Cancer Center and Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA.
  6. 6Department of Respiratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6.
  7. 7Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA.
  8. 8Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  1. To whom correspondence should be addressed. E-mail: aspira{at}bu.edu (A.S.); andreab{at}genetics.utah.edu (A.H.B.)

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