PerspectiveAcute Lymphoblastic Leukemia

Of Mice and Men: How an Oncogene Transgresses the Limits and Predisposes to T Cell Acute Lymphoblastic Leukemia

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Science Translational Medicine  03 Mar 2010:
Vol. 2, Issue 21, pp. 21ps10
DOI: 10.1126/scitranslmed.3000885

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The gene encoding LIM-only 2 (LMO2), an oncogenic transcription factor, is frequently activated in T cell acute lymphoblastic leukemia (T-ALL), but how LMO2 transforms primary hematopoietic cells to induce T-ALL remains an open question. McCormack et al. now show that, in mice, Lmo2 confers self-renewal potential on normally nonrenewing thymocyte progenitor cells, and this property is maintained over four serial transplantations when the cells are transplanted into irradiated mice that lack thymocytes. These leukemia-initiating cells are resistant to irradiation, indicating the need to develop new therapeutic drugs that specifically target the oncogene itself.


  • Citation: T. Hoang, Of mice and men: How an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia. Sci. Transl. Med. 2, 21ps10 (2010).

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