PerspectiveCancer

Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic

Science Translational Medicine  13 Jan 2010:
Vol. 2, Issue 14, pp. 14ps2
DOI: 10.1126/scitranslmed.3000313

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Abstract

Omics technologies are expected to enhance our understanding of a variety of diseases and to open the door to patient-specific personalized medicine. Despite the extensive literature on the use of gene expression arrays to predict prognosis in cancer patients, poor progress has been made in the translation of gene expression signatures for use in the clinics. Breast cancer provides a ripe arena for an analysis of why such signatures have failed to fulfill their promise.

Footnotes

  • Citation: S. Koscielny, Why most gene expression signatures of tumors have not been useful in the clinic. Sci. Transl. Med. 2, 14ps2 (2010).

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