Research ArticleCancer

Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion

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Science Translational Medicine  09 Jan 2019:
Vol. 11, Issue 474, eaat5690
DOI: 10.1126/scitranslmed.aat5690

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Insider attack on tumors

A major factor that limits the effectiveness of cancer therapy is the ability to get the treatment to tumor cells. A variety of microparticles and nanoparticles have been developed in the past, and each of them has its own advantages and limitations. Guo et al. have now developed a method of creating microparticles from the patients’ own cancer cells, resulting in improved intratumoral delivery. The authors embedded the chemotherapy drug methotrexate inside the microparticles and then successfully tested this approach in both mouse models and patients with pleural effusions caused by lung cancer.