Research ArticleTuberculosis

Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

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Science Translational Medicine  05 Dec 2018:
Vol. 10, Issue 470, eaau0965
DOI: 10.1126/scitranslmed.aau0965

Article Information

vol. 10 no. 470

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 14, 2018
  • Resubmitted August 1, 2018
  • Accepted for publication November 2, 2018

Author Information

  1. Elizabeth W. Tucker1,2,3,4,*,
  2. Beatriz Guglieri-Lopez5,*,
  3. Alvaro A. Ordonez1,2,6,*,
  4. Brittaney Ritchie1,2,3,
  5. Mariah H. Klunk1,2,6,
  6. Richa Sharma1,2,6,
  7. Yong S. Chang1,2,6,
  8. Julian Sanchez-Bautista1,2,6,
  9. Sarah Frey1,7,
  10. Martin A. Lodge7,
  11. Steven P. Rowe7,
  12. Daniel P. Holt7,
  13. Jogarao V. S. Gobburu5,
  14. Charles A. Peloquin8,
  15. William B. Mathews7,
  16. Robert F. Dannals7,
  17. Carlos A. Pardo9,
  18. Sujatha Kannan3,
  19. Vijay D. Ivaturi5, and
  20. Sanjay K. Jain1,2,6,7,
  1. 1Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  2. 2Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  3. 3Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  4. 4Division of Pediatric Critical Care, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, USA.
  5. 5Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  6. 6Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  7. 7Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  8. 8Infectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.
  9. 9Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  1. Corresponding author. Email: vivaturi{at}rx.umaryland.edu (V.D.I.); sjain5{at}jhmi.edu (S.K.J.)
  • * These authors contributed equally to this work.

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