Research ArticleTuberculosis

Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

See allHide authors and affiliations

Science Translational Medicine  05 Dec 2018:
Vol. 10, Issue 470, eaau0965
DOI: 10.1126/scitranslmed.aau0965

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

TB on the brain

Children and immunodeficient individuals are especially prone to tuberculosis infections in the brain, causing tuberculous meningitis. Tucker et al. used a rabbit model of tuberculous meningitis and PET imaging to better understand drug distribution. They found that despite sufficient drug concentration in the plasma, rifampin was not penetrating the TB lesions in the brain. These findings were reflected in the imaging of a human patient with tuberculous meningitis. Pharmacokinetic modeling revealed that dosing in pediatric patients would likely need to be adjusted to allow for sufficient rifampin penetration into affected brain areas.