Research ArticleCancer Imaging

68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging

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Science Translational Medicine  07 Nov 2018:
Vol. 10, Issue 466, eaau4445
DOI: 10.1126/scitranslmed.aau4445

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Metastatic melanoma (skin cancer) has a high mortality rate. Yang et al. designed radiolabeled positron emission tomography and fluorescent imaging probes targeting melanocortin-1 receptor, which is overexpressed in melanoma cells. The probes detected melanoma cells in vitro, in xenografts and mouse models, and in metastases in two patients with melanoma. These results suggest that melanocortin-1 receptor-targeting probes may be useful for melanoma imaging.