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Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

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Science Translational Medicine  26 Sep 2018:
Vol. 10, Issue 460, eaat7520
DOI: 10.1126/scitranslmed.aat7520

Article Information

vol. 10 no. 460

PubMed: 
Print ISSN: 
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History: 
  • Received for publication April 30, 2018
  • Accepted for publication September 6, 2018

Author Information

  1. Christopher H. Goss1,2,
  2. Yukihiro Kaneko3,
  3. Lisa Khuu4,
  4. Gail D. Anderson5,
  5. Sumedha Ravishankar4,
  6. Moira L. Aitken1,
  7. Noah Lechtzin6,
  8. Guolin Zhou7,
  9. Daniel M. Czyz8,
  10. Kathryn McLean9,
  11. Oyebode Olakanmi10,
  12. Howard A. Shuman8,
  13. Mary Teresi11,
  14. Ellen Wilhelm1,
  15. Ellen Caldwell1,
  16. Stephen J. Salipante9,
  17. Douglas B. Hornick11,
  18. Richard J. Siehnel4,
  19. Lev Becker7,
  20. Bradley E. Britigan12 and
  21. Pradeep K. Singh4,1,*
  1. 1Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
  2. 2Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.
  3. 3Department of Bacteriology, Osaka City University School of Medicine, Osaka 545-0051, Japan.
  4. 4Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  5. 5Department of Pharmacy, University of Washington School of Pharmacy, Seattle, WA 98195, USA.
  6. 6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  7. 7Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
  8. 8Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
  9. 9Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
  10. 10University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
  11. 11Departments of Medicine and Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
  12. 12Department of Medicine, University of Nebraska School of Medicine, Omaha, NE 68105, USA.
  1. *Corresponding author. Email: singhpr{at}uw.edu

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Article usage: September 2018 to October 2018

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