A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

Marc D. Ruben; Gang Wu; David F. Smith; Robert E. Schmidt; Lauren J. Francey; Yin Yeng Lee; Ron C. Anafi; John B. Hogenesch

doi:10.1126/scitranslmed.aat8806

Research ResourceCIRCADIAN MEDICINE

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

Marc D. Ruben¹,
Gang Wu¹,
David F. Smith²,³,
Robert E. Schmidt¹,
Lauren J. Francey¹,
Yin Yeng Lee¹,
Ron C. Anafi⁴ and
John B. Hogenesch ¹,*

¹Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.
²Divisions of Pediatric Otolaryngology and Pulmonary and Sleep Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
³Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.
⁴Department of Medicine, Center for Sleep and Circadian Neurobiology, Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

↵*Corresponding author. Email: john.hogenesch{at}cchmc.org

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Science Translational Medicine 12 Sep 2018:
Vol. 10, Issue 458, eaat8806
DOI: 10.1126/scitranslmed.aat8806

Marc D. Ruben

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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Gang Wu

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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David F. Smith

Divisions of Pediatric Otolaryngology and Pulmonary and Sleep Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

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Robert E. Schmidt

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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Lauren J. Francey

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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Yin Yeng Lee

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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Ron C. Anafi

Department of Medicine, Center for Sleep and Circadian Neurobiology, Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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John B. Hogenesch

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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For correspondence: john.hogenesch@cchmc.org

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A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

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