Research ArticleOsteoarthritis

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

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Science Translational Medicine  12 Sep 2018:
Vol. 10, Issue 458, eaar8426
DOI: 10.1126/scitranslmed.aar8426

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Oxidative stress and osteoarthritis

Osteoarthritis is a common degenerative joint disorder that affects cartilage and bone. Cornelis et al. investigated the role of ANP32A, a protein involved in multiple cellular processes, in osteoarthritis. ANP32A was decreased in osteoarthritic human and mouse tissue samples and also decreased with aging. The authors found that ANP32A promoted transcription of ATM and regulated reactive oxygen species in cartilage. Antioxidant therapy protected Anp32a-deficient mice from developing osteoarthritis and osteopenia and also rescued neurological defects caused by lack of ATM and increased oxidative stress. These results suggest that ANP32A could be a therapeutic target for correcting imbalanced reactive oxygen species and antioxidants.