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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

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Science Translational Medicine  29 Aug 2018:
Vol. 10, Issue 456, eaar3483
DOI: 10.1126/scitranslmed.aar3483

Article Information

vol. 10 no. 456

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 30, 2017
  • Resubmitted February 7, 2018
  • Accepted for publication August 9, 2018

Author Information

  1. Huiping Ding1,*,
  2. Norikazu Kiguchi1,2,*,
  3. Dennis Yasuda3,
  4. Pankaj R. Daga3,
  5. Willma E. Polgar3,
  6. James J. Lu3,
  7. Paul W. Czoty1,
  8. Shiroh Kishioka2,
  9. Nurulain T. Zaveri3, and
  10. Mei-Chuan Ko1,4,
  1. 1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  2. 2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.
  3. 3Astraea Therapeutics, Mountain View, CA 94043, USA.
  4. 4W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.
  1. Corresponding author. Email: nurulain{at}astraeatherapeutics.com (N.T.Z.); mko{at}wakehealth.edu (M.-C.K.)
    • * These authors contributed equally to this work.

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    Aug 20180140661914
    Sep 20183414150422892
    Oct 20187534392206
    Nov 20181557156104