Research ArticleObesity

Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

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Science Translational Medicine  22 Aug 2018:
Vol. 10, Issue 455, eaah6324
DOI: 10.1126/scitranslmed.aah6324

Article Information

vol. 10 no. 455

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 25, 2016
  • Resubmitted May 1, 2017
  • Accepted for publication March 22, 2018

Author Information

  1. Rafi Mazor1,*,,
  2. Dinorah Friedmann-Morvinski2,3,4,*,,
  3. Tom Alsaigh1,
  4. Oded Kleifeld5,
  5. Erik B. Kistler1,6,7,
  6. Liat Rousso-Noori3,4,
  7. Cheng Huang5,
  8. Joyce B. Li1,
  9. Inder M. Verma2 and
  10. Geert W. Schmid-Schönbein1
  1. 1Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  3. 3Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
  4. 4Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
  5. 5Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
  6. 6Veterans Affairs San Diego Healthcare System, San Diego, CA 92093, USA.
  7. 7Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA 92093, USA.
  1. Corresponding author. Email: rmazor{at}ucsd.edu (R.M.); dino{at}post.tau.ac.il (D.F.-M.)
    • * These authors contributed equally to this work.

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