Research ArticleBRAIN TUMORS

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

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Science Translational Medicine  15 Aug 2018:
Vol. 10, Issue 454, eaar2718
DOI: 10.1126/scitranslmed.aar2718

Article Information

vol. 10 no. 454

Print ISSN: 
Online ISSN: 
  • Received for publication October 23, 2017
  • Resubmitted April 24, 2018
  • Accepted for publication July 25, 2018

Author Information

  1. Euan S. Polson1,*,
  2. Verena B. Kuchler1,*,
  3. Christopher Abbosh1,,
  4. Edith M. Ross2,
  5. Ryan K. Mathew1,3,
  6. Hester A. Beard4,
  7. Bárbara da Silva1,
  8. Andrew N. Holding2,
  9. Stephane Ballereau2,
  10. Eulashini Chuntharpursat-Bon1,
  11. Jennifer Williams1,
  12. Hollie B.S. Griffiths5,
  13. Hao Shao6,
  14. Anjana Patel1,
  15. Adam J. Davies1,
  16. Alastair Droop1,
  17. Paul Chumas3,
  18. Susan C. Short1,
  19. Mihaela Lorger1,
  20. Jason E. Gestwicki6,
  21. Lee D. Roberts1,
  22. Robin S. Bon1,4,
  23. Simon J. Allison5,
  24. Shoutian Zhu7,,
  25. Florian Markowetz2 and
  26. Heiko Wurdak1,§
  1. 1School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
  2. 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.
  3. 3Department of Neurosurgery, Leeds General Infirmary, Leeds LS1 3EX, UK.
  4. 4School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
  5. 5School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.
  6. 6Department of Pharmaceutical Chemistry and the Institute for Neurodegenerative Disease, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA.
  7. 7California Institute for Biomedical Research, 11119 North Torrey Pines Road, Suite 100, La Jolla, CA 92037, USA.
  1. §Corresponding author. Email: h.wurdak{at}
    • * These authors contributed equally to this work.

    • Present address: Cancer Research UK Lung Cancer Centre of Excellence at London and Manchester, University College London Cancer Institute, 72 Huntley Street, London WC1E 6DD, UK.

    • Present address: Regulus Therapeutics Inc., 10614 Science Center Drive, San Diego, CA 92121, USA.


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