Research ArticleAutoimmunity

Laminin 511 is a target antigen in autoimmune pancreatitis

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Science Translational Medicine  08 Aug 2018:
Vol. 10, Issue 453, eaaq0997
DOI: 10.1126/scitranslmed.aaq0997

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  • RE: Shiokawa et al.: Laminin 511 is a target antigen in autoimmune pancreatitis. Science Translational Medicine 10, eaaq0997 (2018)
    • J.-Matthias Löhr, Professor of Gastroenterology & Hepatology, Karolinska Institutet
    • Other Contributors:
      • Manuel Patarroyo, Professor of Immunology, Karolinska Institutet

    With great interest we have read the recent contribution by Shiokawa and colleagues on the detection of novel antibodies against one laminin isoform in a subgroup of patients with autoimmune pancreatitis (AIP) type I (1). We would like to contribute to the discussion with additional insights that may enhance the importance of their findings.
    Several autoantibodies have been described in AIP, most of them mentioned in their paper. Looking at the histopathology, the inflammation clearly affects both the ductal as well as the acinar cells (2). All hitherto described autoantibodies are directed against intracellular antigens in epithelial cells: in the ductal compartment against carbonic anhydrase type II(3) and annexin A11(4), and in the acinar compartment against lactoferrin(3), amylase(5), the trypsin inhibitor PSTI (SPINK1)(6, 7), and trypsinogens(7), to name those confirmed(8).
    Together with collagen type IV(9), laminin 511 represents the second autoantigen of extracellular matrix proteins (ECM), specifically (those) from the basement membrane, common to both ductal as well as acinar cells. Since laminin 511 as well as collagen type IV are widely expressed throughout the entire body, one would expect contribution of an additional pancreas-specific element making these proteins to autoantigens. One possible mechanism could be the unraveling during the process of the dying acinar cells, as a result of the damaging effect of the “primary” autoantibodies specific...

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    Competing Interests: None declared.