Research ArticlePain

MicroRNA-30c-5p modulates neuropathic pain in rodents

See allHide authors and affiliations

Science Translational Medicine  08 Aug 2018:
Vol. 10, Issue 453, eaao6299
DOI: 10.1126/scitranslmed.aao6299

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Targeting a microRNA for neuropathic pain

Neuropathic pain is a debilitating condition resulting from nerve damage. Often, patients do not achieve pain relief with currently available therapies. A better understanding of the mechanisms mediating neuropathic pain could help to identify more effective therapies. Now, Tramullas et al. show that neuropathic pain in rodents was associated with increased expression of the microRNA miR-30c-5p in the brain, cerebrospinal fluid, and plasma. In addition, miR-30c-5p was up-regulated in plasma and cerebrospinal fluid from patients with peripheral ischemia–induced pain. Inhibiting this microRNA in the rodent model produced analgesic effects. The results suggest that targeting miR-30c-5p might be an effective strategy for treating neuropathic pain.