Research ArticleCancer

Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)

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Science Translational Medicine  08 Aug 2018:
Vol. 10, Issue 453, eaan0941
DOI: 10.1126/scitranslmed.aan0941

Article Information

vol. 10 no. 453

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 3, 2017
  • Resubmitted March 29, 2018
  • Accepted for publication July 20, 2018

Author Information

  1. Masturah Bte Mohd Abdul Rashid1,2,
  2. Tan Boon Toh1,
  3. Lissa Hooi1,
  4. Aleidy Silva3,
  5. Yanzhou Zhang1,
  6. Pei Fang Tan4,
  7. Ai Ling Teh4,
  8. Neerja Karnani4,5,
  9. Sudhakar Jha1,5,
  10. Chih-Ming Ho3,6,7,
  11. Wee Joo Chng1,8,
  12. Dean Ho2,6,7,9,10,11 and
  13. Edward Kai-Hua Chow1,2,*
  1. 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
  2. 2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  3. 3Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  4. 4Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
  5. 5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
  6. 6Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  7. 7Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  8. 8Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore 119228, Singapore.
  9. 9Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
  10. 10Bioengineering Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
  11. 11Division of Oral Biology and Medicine and the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  1. *Corresponding author. Email: csikce{at}nus.edu.sg

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