Research ArticleINFLAMMATORY BOWEL DISEASE
An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis
- Tetsuya Takagawa1,2,
- Atsushi Kitani2,
- Ivan Fuss2,
- Beth Levine3,
- Steven R. Brant4,
- Inga Peter5,
- Masaki Tajima2,
- Shiro Nakamura1 and
- Warren Strober2,*
- 1Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
- 2Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Departments of Internal Medicine and Microbiology, Center for Autophagy Research, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 4Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins School of Medicine, and Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA.
- 5Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- ↵*Corresponding author. Email: wstrober{at}niaid.nih.gov
See allHide authors and affiliations
Science Translational Medicine 06 Jun 2018:
Vol. 10, Issue 444, eaan8162
DOI: 10.1126/scitranslmed.aan8162
