Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy

Elena Dossi; Thomas Blauwblomme; Julien Moulard; Oana Chever; Flora Vasile; Eleonore Guinard; Marc Le Bert; Isabelle Couillin; Johan Pallud; Laurent Capelle; Gilles Huberfeld; Nathalie Rouach

doi:10.1126/scitranslmed.aar3796

Research ArticleEpilepsy

Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy

Elena Dossi ¹,
Thomas Blauwblomme²,³,*,
Julien Moulard¹,*,
Oana Chever¹,
Flora Vasile¹,
Eleonore Guinard¹,³,
Marc Le Bert⁴,
Isabelle Couillin⁴,
Johan Pallud⁵,
Laurent Capelle⁶,
Gilles Huberfeld¹,³,⁷ and
Nathalie Rouach ¹,†

¹Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, CNR UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, 75005 Paris, France.
²Assistance Publique-Hopitaux de Paris (AP-HP), Department of Pediatric Neurosurgery, Necker Hospital, INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, 75015 Paris, France.
³INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, CEA, 75015 Paris, France.
⁴CNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45067 Orléans, France.
⁵Department of Neurosurgery, Sainte-Anne Hospital and IMA-BRAIN, INSERM U894, Paris Descartes University, PRES Sorbonne Paris Cité, 75014 Paris, France.
⁶Department of Neurosurgery, University Pierre and Marie Curie, La Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Universités, 75013 Paris, France.
⁷Department of Neurophysiology, La Pitié-Salpetrière Hospital, Sorbonne Universités, University Pierre and Marie Curie, AP-HP, 75013 Paris, France.

↵†Corresponding author. Email: nathalie.rouach{at}college-de-france.fr

↵* These authors contributed equally to this work.

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Science Translational Medicine 30 May 2018:
Vol. 10, Issue 443, eaar3796
DOI: 10.1126/scitranslmed.aar3796

Elena Dossi

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Thomas Blauwblomme

Assistance Publique-Hopitaux de Paris (AP-HP), Department of Pediatric Neurosurgery, Necker Hospital, INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, 75015 Paris, France.INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, CEA, 75015 Paris, France.

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Julien Moulard

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Oana Chever

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Flora Vasile

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Eleonore Guinard

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Marc Le Bert

CNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45067 Orléans, France.

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Isabelle Couillin

CNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45067 Orléans, France.

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Johan Pallud

Department of Neurosurgery, Sainte-Anne Hospital and IMA-BRAIN, INSERM U894, Paris Descartes University, PRES Sorbonne Paris Cité, 75014 Paris, France.

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Laurent Capelle

Department of Neurosurgery, University Pierre and Marie Curie, La Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Universités, 75013 Paris, France.

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Gilles Huberfeld

Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, CNR UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, 75005 Paris, France.INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, CEA, 75015 Paris, France.Department of Neurophysiology, La Pitié-Salpetrière Hospital, Sorbonne Universités, University Pierre and Marie Curie, AP-HP, 75013 Paris, France.

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Nathalie Rouach

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For correspondence: nathalie.rouach@college-de-france.fr

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Pannexin-1 channel inhibition blocks seizure activity in brain slices from epileptic patients and reduces spontaneous seizures in a mouse model of pharmacoresistant epilepsy.

Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy

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