Research ArticleEpilepsy

Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy

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Science Translational Medicine  30 May 2018:
Vol. 10, Issue 443, eaar3796
DOI: 10.1126/scitranslmed.aar3796

Article Information

vol. 10 no. 443

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  • Received for publication January 24, 2017
  • Resubmitted November 2, 2017
  • Accepted for publication May 10, 2018

Author Information

  1. Elena Dossi1,
  2. Thomas Blauwblomme2,3,*,
  3. Julien Moulard1,*,
  4. Oana Chever1,
  5. Flora Vasile1,
  6. Eleonore Guinard1,3,
  7. Marc Le Bert4,
  8. Isabelle Couillin4,
  9. Johan Pallud5,
  10. Laurent Capelle6,
  11. Gilles Huberfeld1,3,7 and
  12. Nathalie Rouach1,
  1. 1Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, CNR UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, 75005 Paris, France.
  2. 2Assistance Publique-Hopitaux de Paris (AP-HP), Department of Pediatric Neurosurgery, Necker Hospital, INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, 75015 Paris, France.
  3. 3INSERM U1129, Paris Descartes University, PRES Sorbonne Paris Cité, CEA, 75015 Paris, France.
  4. 4CNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45067 Orléans, France.
  5. 5Department of Neurosurgery, Sainte-Anne Hospital and IMA-BRAIN, INSERM U894, Paris Descartes University, PRES Sorbonne Paris Cité, 75014 Paris, France.
  6. 6Department of Neurosurgery, University Pierre and Marie Curie, La Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Universités, 75013 Paris, France.
  7. 7Department of Neurophysiology, La Pitié-Salpetrière Hospital, Sorbonne Universités, University Pierre and Marie Curie, AP-HP, 75013 Paris, France.
  1. Corresponding author. Email: nathalie.rouach{at}
    • * These authors contributed equally to this work.


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    May 20182583106151
    Jun 20185413166310
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