Research ArticlePUBLIC HEALTH

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

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Science Translational Medicine  30 May 2018:
Vol. 10, Issue 443, eaan4116
DOI: 10.1126/scitranslmed.aan4116

Article Information

vol. 10 no. 443

PubMed: 
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History: 
  • Received for publication April 14, 2017
  • Resubmitted February 9, 2018
  • Accepted for publication April 13, 2018

Author Information

  1. Haixia Yang1,2,*,
  2. Weicang Wang1,*,
  3. Kymberleigh A. Romano3,
  4. Min Gu1,
  5. Katherine Z. Sanidad1,4,
  6. Daeyoung Kim5,
  7. Jun Yang6,
  8. Birgitta Schmidt7,
  9. Dipak Panigrahy8,
  10. Ruisong Pei9,
  11. Derek A. Martin9,
  12. E. Ilker Ozay4,10,
  13. Yuxin Wang1,11,
  14. Mingyue Song1,
  15. Bradley W. Bolling9,
  16. Hang Xiao1,4,
  17. Lisa M. Minter4,10,
  18. Guang-Yu Yang12,
  19. Zhenhua Liu4,13,
  20. Federico E. Rey3, and
  21. Guodong Zhang1,4,
  1. 1Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
  2. 2Department of Nutrition and Food Safety, College of Public Health, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China.
  3. 3Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
  4. 4Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.
  5. 5Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA 01003, USA.
  6. 6Department of Entomology and Nematology, University of California, Davis, Davis, CA 95616, USA.
  7. 7Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  8. 8Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  9. 9Department of Food Science, University of Wisconsin-Madison, Madison, WI 53706, USA.
  10. 10Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.
  11. 11College of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China.
  12. 12Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  13. 13Department of Nutrition, University of Massachusetts, Amherst, MA 01003, USA.
  1. Corresponding author. Email: guodongzhang{at}umass.edu (G.Z.); ferey{at}wisc.edu (F.E.R.)
    • * These authors contributed equally to this work.

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    May 20185817195288
    Jun 201835888433653
    Jul 20189041176225
    Aug 20181563132115
    Sep 2018891128112
    Oct 2018126417277
    Nov 20183743724