PerspectiveCancer

Cancer metabolism gets physical

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Science Translational Medicine  23 May 2018:
Vol. 10, Issue 442, eaaq1011
DOI: 10.1126/scitranslmed.aaq1011

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Abstract

Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.

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