Research ArticleCancer

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

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Science Translational Medicine  16 May 2018:
Vol. 10, Issue 441, eaap8307
DOI: 10.1126/scitranslmed.aap8307

Article Information

vol. 10 no. 441

PubMed: 
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History: 
  • Received for publication September 19, 2017
  • Accepted for publication April 24, 2018

Author Information

  1. Kevin J. Frankowski1,*,,
  2. Chen Wang2,,
  3. Samarjit Patnaik3,
  4. Frank J. Schoenen1,
  5. Noel Southall3,
  6. Dandan Li4,
  7. Yaroslav Teper4,
  8. Wei Sun3,
  9. Irawati Kandela5,
  10. Deqing Hu6,
  11. Christopher Dextras3,
  12. Zachary Knotts4,
  13. Yansong Bian4,
  14. John Norton2,
  15. Steve Titus3,
  16. Marzena A. Lewandowska2,
  17. Yiping Wen2,
  18. Katherine I. Farley7,
  19. Lesley Mathews Griner3,
  20. Jamey Sultan3,
  21. Zhaojing Meng8,
  22. Ming Zhou8,
  23. Tomas Vilimas9,
  24. Astin S. Powers10,
  25. Serguei Kozlov9,
  26. Kunio Nagashima11,
  27. Humair S. Quadri4,
  28. Min Fang12,
  29. Charles Long2,
  30. Ojus Khanolkar2,
  31. Warren Chen2,
  32. Jinsol Kang2,
  33. Helen Huang2,
  34. Eric Chow2,
  35. Esthermanya Goldberg2,
  36. Coral Feldman2,
  37. Romi Xi2,
  38. Hye Rim Kim13,
  39. Gary Sahagian12,
  40. Susan J. Baserga7,
  41. Andrew Mazar5,
  42. Marc Ferrer3,
  43. Wei Zheng3,
  44. Ali Shilatifard6,
  45. Jeffrey Aubé1,*,
  46. Udo Rudloff4,,
  47. Juan Jose Marugan3, and
  48. Sui Huang2,
  1. 1Specialized Chemistry Center, The University of Kansas, Lawrence, KS 66047, USA.
  2. 2Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA.
  3. 3NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA.
  4. 4Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  5. 5Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA.
  6. 6Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  7. 7Departments of Molecular Biophysics and Biochemistry, Genetics, and Therapeutic Radiology, Yale University and Yale School of Medicine, New Haven, CT 06520, USA.
  8. 8Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.
  9. 9Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Fort Detrick, Frederick, MD 21702, USA.
  10. 10Laboratory of Pathology, Center for Cancer Research, NIH, Bethesda, MD 20892, USA.
  11. 11Electron Microscope Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  12. 12Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
  13. 13Department of Human Genetics, Cancer Biology Graduate Program, Emory University School of Medicine, Atlanta, GA 30322, USA.
  1. Corresponding author. Email: s-huang2{at}northwestern.edu (S.H.); maruganj{at}mail.nih.gov (J.J.M.); rudloffu{at}mail.nih.gov (U.R.)
    • * Present address: UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599–7363, USA.

    • These authors contributed equally to this work.

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