Research ArticleCancer

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

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Science Translational Medicine  16 May 2018:
Vol. 10, Issue 441, eaap8307
DOI: 10.1126/scitranslmed.aap8307

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Blocking metastasis from the inside

Metastasis, the spread of tumor cells that often results in cancer patients’ deaths, remains difficult to treat for all cancer types. To intervene with this process, Frankowski et al. searched for inhibitors of the perinucleolar compartment, a structure located within the nuclei of cancer cells and associated with metastatic capacity. Through high-throughput screening followed by chemical optimization, the authors developed a compound they called metarrestin, which disrupts the perinuclear compartment in different types of cancer cells. They discovered that metarrestin inhibited tumor invasion and metastasis in multiple mouse models of cancer and prolonged the animals’ survival, suggesting its potential relevance for translation to patients.