Research ArticleTissue Engineering

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

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Science Translational Medicine  09 May 2018:
Vol. 10, Issue 440, eaan4587
DOI: 10.1126/scitranslmed.aan4587

Article Information

vol. 10 no. 440

Print ISSN: 
Online ISSN: 
  • Received for publication April 18, 2017
  • Resubmitted September 20, 2017
  • Accepted for publication April 9, 2018

Author Information

  1. Maximilian Y. Emmert1,2,3,*,
  2. Boris A. Schmitt4,5,*,
  3. Sandra Loerakker6,7,*,
  4. Bart Sanders6,7,*,
  5. Hendrik Spriestersbach4,5,
  6. Emanuela S. Fioretta1,
  7. Leon Bruder4,5,
  8. Kerstin Brakmann4,5,
  9. Sarah E. Motta1,
  10. Valentina Lintas1,
  11. Petra E. Dijkman1,
  12. Laura Frese1,
  13. Felix Berger4,5,,
  14. Frank P. T. Baaijens6,7, and
  15. Simon P. Hoerstrup1,3,,
  1. 1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  2. 2University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
  3. 3Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
  4. 4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
  5. 5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
  6. 6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
  7. 7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
  1. Corresponding author. Email: simon.hoerstrup{at}
    • * These authors contributed equally to this work as first authors.

    • These authors contributed equally to this work as last authors.


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    Article usage: May 2018 to December 2018

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