Research ArticleSpinal Cord Injury

Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs

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Science Translational Medicine  09 May 2018:
Vol. 10, Issue 440, eaam6651
DOI: 10.1126/scitranslmed.aam6651

Article Information

vol. 10 no. 440

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 25, 2016
  • Resubmitted November 17, 2017
  • Accepted for publication April 19, 2018

Author Information

  1. Jan Strnadel1,2,
  2. Cassiano Carromeu3,
  3. Cedric Bardy4,5,
  4. Michael Navarro1,
  5. Oleksandr Platoshyn1,
  6. Andreas N. Glud1,
  7. Silvia Marsala1,
  8. Jozef Kafka1,
  9. Atsushi Miyanohara1,6,
  10. Tomohisa Kato Jr.7,
  11. Takahiro Tadokoro1,
  12. Michael P. Hefferan1,
  13. Kota Kamizato1,
  14. Tetsuya Yoshizumi1,
  15. Stefan Juhas8,
  16. Jana Juhasova8,
  17. Chak-Sum Ho9,
  18. Taba Kheradmand9,
  19. PeiXi Chen1,
  20. Dasa Bohaciakova1,10,
  21. Marian Hruska-Plochan1,11,
  22. Andrew J. Todd12,
  23. Shawn P. Driscoll13,
  24. Thomas D. Glenn13,
  25. Samuel L. Pfaff13,
  26. Jiri Klima8,
  27. Joseph Ciacci14,
  28. Eric Curtis14,
  29. Fred H. Gage4,
  30. Jack Bui15,
  31. Kazuhiko Yamada16,
  32. Alysson R. Muotri3 and
  33. Martin Marsala1,17,*
  1. 1Neuroregeneration Laboratory, Department of Anesthesiology, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
  2. 2Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
  3. 3Department of Pediatrics, UCSD, La Jolla, CA 92037, USA.
  4. 4Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  5. 5Laboratory for Human Neurophysiology and Genetics, South Australian Health & Medical Research Institute (SAHMRI) Mind and Brain, Adelaide, South Australia, Australia.
  6. 6Vector Development Core Laboratory, UCSD, La Jolla, CA 92093, USA.
  7. 7Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
  8. 8Institute of Animal Physiology and Genetics, v.v.i., The Czech Academy of Sciences, Liběchov, Czech Republic.
  9. 9Histocompatibility Laboratory, Gift of Life Michigan, Ann Arbor, MI 48108, USA.
  10. 10Department of Histology and Embryology, Masaryk University, Brno, Czech Republic.
  11. 11Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
  12. 12Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  13. 13Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  14. 14Department of Neurosurgery, UCSD, La Jolla, CA 92103, USA.
  15. 15Department of Pathology, UCSD, La Jolla, CA 92093, USA.
  16. 16Columbia University Medical Center Campus, New York, NY 10032, USA.
  17. 17Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia.
  1. *Corresponding author. Email: mmarsala{at}ucsd.edu

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Oct 2018852325