FocusCancer

ER stress in prostate cancer: A therapeutically exploitable vulnerability?

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Science Translational Medicine  02 May 2018:
Vol. 10, Issue 439, eaat3975
DOI: 10.1126/scitranslmed.aat3975

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Abstract

Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al., this issue).

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