Contents

25 April 2018
Vol 10, Issue 438
  • Focus

    • Human fetal immune cells fight back

      Immune dysregulation begins in utero, influenced by inflammation, maternal micro-chimerism, and the activation of fetal immune responses (Frascoli et al., this issue).

  • Research Articles

    • Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

      Human fetal T cell activation against maternal antigens could promote uterine contractions in preterm labor.

    • A digital microfluidic system for serological immunoassays in remote settings

      Portable digital microfluidic serological immunoassays for measles and rubella were developed and evaluated in a remote setting.

    • PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

      Oral pioglitazone reverses pulmonary hypertensive vascular disease and prevents right heart failure via epigenetic, transcriptional, and metabolic mechanisms.

    • Targeting protein biotinylation enhances tuberculosis chemotherapy

      Inhibitors of biotin protein ligase and protein biotinylation in Mycobacterium tuberculosis act synergistically with the drug rifampicin, potentially shortening tuberculosis treatment.

  • Perspective

    • Fundamental science behind today’s important medicines

      Today’s most transformative medicines exist because of fundamental discoveries that were made without regard to practical outcome and with their relevance to therapeutics only appearing decades later.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Let's Get Digital. Digital microfluidic devices use electrostatic forces to control the movement of droplets of fluids. This image of a digital microfluidic cartridge is part of an assay developed by Ng et al. to test blood samples for measles- and rubella-reactive IgG. The authors designed inkjet-printed cartridges and used a laptop power supply to run a control box, performing serological surveys using small volumes of blood obtained on-site in a refugee camp in Kenya. By adapting digital microfluidics technology for use in remote locations, the authors have generated a new tool that can be used to advance global health and combat vaccine-preventable outbreaks. [CREDIT: LISA NGO/UNIVERSITY OF TORONTO]