Research ArticleCancer

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

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Science Translational Medicine  11 Apr 2018:
Vol. 10, Issue 436, eaan8292
DOI: 10.1126/scitranslmed.aan8292

Article Information

vol. 10 no. 436

Print ISSN: 
Online ISSN: 
  • Received for publication May 28, 2017
  • Resubmitted January 9, 2018
  • Accepted for publication March 23, 2018

Author Information

  1. Ofir Wolach1,2,3,*,
  2. Rob S. Sellar1,4,5,*,
  3. Kimberly Martinod6,
  4. Deya Cherpokova6,
  5. Marie McConkey1,
  6. Ryan J. Chappell1,
  7. Alexander J. Silver1,
  8. Dylan Adams1,
  9. Cecilia A. Castellano1,
  10. Rebekka K. Schneider1,7,
  11. Robert F. Padera8,
  12. Daniel J. DeAngelo9,
  13. Martha Wadleigh9,
  14. David P. Steensma9,
  15. Ilene Galinsky9,
  16. Richard M. Stone9,
  17. Giulio Genovese5,10,
  18. Steven A. McCarroll5,10,
  19. Bozenna Iliadou11,
  20. Christina Hultman11,
  21. Donna Neuberg9,
  22. Ann Mullally1,5,9,
  23. Denisa D. Wagner6 and
  24. Benjamin L. Ebert1,5,9,
  1. 1Division of Hematology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  2. 2Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel.
  3. 3Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 49100, Israel.
  4. 4Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.
  5. 5Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  6. 6Program in Cellular and Molecular Medicine and Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Department of Hematology, Cancer Institute, Erasmus Medical Center, Rotterdam 2040, Netherlands.
  8. 8Department of Pathology, Brigham and Women’s Hospital, Boston Children’s Hospital, and Harvard Medical School, Boston, MA 02115, USA.
  9. 9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  10. 10Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  11. 11Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 76, Sweden.
  1. Corresponding author. Email: bebert{at}
    • * These authors contributed equally to this work.


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