ReviewCardiovascular Disease

Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

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Science Translational Medicine  04 Apr 2018:
Vol. 10, Issue 435, eaah5457
DOI: 10.1126/scitranslmed.aah5457

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Abstract

Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

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