Editors' ChoiceMyocardial Infarction

Hidden agendas: Clonal hematopoiesis accelerates heart failure

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Science Translational Medicine  28 Mar 2018:
Vol. 10, Issue 434, eaat3885
DOI: 10.1126/scitranslmed.aat3885

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Abstract

Clonal hematopoiesis driven by TET2 deficiency accelerates post-infarct remodeling and heart failure through the NLRP3 inflammasome and IL-1β production.

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