Research ArticleCancer

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

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Science Translational Medicine  21 Mar 2018:
Vol. 10, Issue 433, eaap8793
DOI: 10.1126/scitranslmed.aap8793

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Brushing up on early cancer detection

Despite the many recent advances in cancer diagnosis and treatment, ovarian cancer remains one of the most lethal malignancies, in part because there are no accurate screening methods for this disease and it is often diagnosed at a late stage. To develop a screening tool for ovarian and endometrial cancers, Wang et al. combined genetic analysis of fluids obtained through routine Papanicolau testing, normally done for cervical cancer, with analysis of tumor DNA circulating in the blood. The authors also used intrauterine sampling with Tao brushes to further increase the sensitivity of detection for the less accessible tumors.