Research ArticleFibrosis

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

See allHide authors and affiliations

Science Translational Medicine  10 Jan 2018:
Vol. 10, Issue 423, eaam8458
DOI: 10.1126/scitranslmed.aam8458

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Plasmacytoid DCs foster fibrosis

As potent producers of type I interferon, plasmacytoid dendritic cells (pDCs) have been implicated in multiple autoimmune disorders. Here, Ah Kioon and colleagues show that pDCs contribute to skin fibrosis in systemic sclerosis, largely through activation of TLR8, which is not normally expressed in these cells, and secretion of CXCL4. These data were garnered from systemic sclerosis patient samples and mouse models. Depletion of pDCs from mice with established fibrosis ameliorated disease symptoms, further suggesting that targeting these cells could help patients with this devastating disease.